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KMID : 0357920120460050415
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Korean Journal of Pathology
2012 Volume.46 No. 5 p.415 ~ p.422
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DPC4 Expression in the Small Intestinal Adenocarcinomas
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Lee Sun-Jae
Yu Eun-Sil
Bae Young-Kyung
Jang Kee-Taek
Kim Joon-Mee
Bae Han-Ik
Hong Seung-Mo
Yoon Ghil-Suk
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Abstract
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Background : Small intestinal adenocarcinomas (SACs) are rare malignancies of the alimentary tract with uncertain carcinogenesis.
Methods : We investigated the expression of deleted in pancreatic cancer 4 (DPC4) in 188 cases of surgically resected SACs, using tissue microarray technology.
Results : Twenty-four of the 188 tumors showed complete loss of Smad4/DPC4 expression in cytoplasm (score, 0; 12.8%). Eighty-four and 31 cases were moderately and strongly positive, respectively (score, 2 and 3; 44.7% and 16.5%, respectively) and 49 cases were focally or weakly stained (score, 1; 29.1%). Immunohistochemistry analysis showed that the expression of Smad4/DPC4 was related to an increased risk of lymphatic invasion but not to other clinicopathological features of the tumors (tumor location, differentiation, growth pattern, T stage, direct invasion, vascular invasion, and nodal metastasis). There was no significant association between Smad4/DPC4 expression and patient survival.
Conclusions : The present research is the first study to evaluate Smad4/DPC4 expression in a large sample of SACs with clinicopathologic correlation. Future studies should focus on the immunohistochemical and molecular characteristics of SACs to clarify their tumorigenesis.
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KEYWORD
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Smad4/DPC4, Adenocarcinoma, Intestine, small, Immunohistochemistry
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